The gas cartridge filter is NIOSH-approved, making it suitable for situations involving non-oil-based particles. When facing particle contaminants, the 3MTM 501 Retainer is used in conjunction with the 3M gas and vapor cartridges. This combination effectively limits exposure to particulates. Additionally, for enhanced protection against particles, the 3MTM 501 Retainer can be used on top of the 3MTM 603 Filter Holder, further bolstering the respiratory defence.